Synthesis, cardiostimulatory, and cardioinhibitory effects of selected insect peptides on Tenebrio molitor |
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Authors: | K Szymanowska-Dziubasik P Marciniak G Rosiński D Konopińska |
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Affiliation: | 1. Faculty of Chemistry, University of Wroc?aw, 50‐383 Wroc?aw, 14 F. Joliot‐Curie Str., Poland;2. Department of Animal Physiology and Developmental Biology, A. Mickiewicz University, 61‐701 Poznan, Poland |
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Abstract: | The subject of these studies was a search for proctolin antagonists among peptides originating from insect species because the proctolin antagonists constantly pose a problem. During these studies we performed the synthesis of the following peptides: a native decapeptide from Manduca sexta Mas-MT-I and its 11 analogs with shortened sequences at the N-end as well as a growth suppressor, a pentapeptide isolated from Antheraea yamamai, Any-GS and its 10 analogs, modified at position 1 and with a shortened peptide chain.Biological effects were evaluated by the cardiotropic test on the semi-isolated heart of the insect species Tenebrio molitor. Mas-MT-I and six analogs stimulate the heartbeat frequency, especially [6-10]-Mas-MT-I, whereas the [4-10]-Mas-MT-I analog shows a strong inhibition of the heartbeat frequency, if insect. The Any-GS and the analogs [Gln(1)]- and [Gly(1)]-Any-GS also show a strong cardioinhibitory effect. |
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Keywords: | insect myotropins cardiostimulatory peptides of insects cardioinhibitory peptides of insects myotropic peptides from Manduca sexta growth‐suppressing pentapeptides |
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