Protein-protein interactions in signaling cascades |
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Authors: | Bruce J Mayer |
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Institution: | (1) Howard Hughes Medical Institute, Children’s Hospital and Department of Microbiology and Molecular Genetics, Harvard Medical School, 300 Longwod Avenue, 02116 Boston, MA |
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Abstract: | The process of signal transduction is dependent on specific protein-protein interactions. In many cases these interactions
are mediated by modular protein domains that confer specific binding activity to the proteins in which they are found. Rapid
progress has been made in the biochemical characterization of binding interactions, the identification of binding partners,
and determination of the three-dimensional structures of binding modules and their ligands. The resulting information establishes
the logical framework for our current understanding of the signal transduction machinery. In this overview a variety of protein
interaction modules are discussed, and issues relating to binding specificity and the significance of a particular interaction
are considered. |
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Keywords: | Modular domains protein ligands signal transduction specificity |
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