Elevated levels of arylsulfatase C activity in cultured skin fibroblasts of patients with autosomal dominant ichthyosis vulgaris

Summary Assays of arylsulfatase C and steroidsulfatase activities in cultured skin fibroblasts from 20 persons with autosomal dominant ichthyosis and 8 controls showed significantly elecated arylsulfatase C activities in cells from patients with autosomal dominant ichthyosis in comparison with those in control cells. This difference was not detected for steroidsulfatase activity. In leukocytes, activities of arylsulfatase C and of steroidsulfatase were similar for patients and controls.