Cisplatin induced nephrotoxicity and the modulating effect of glutathione ester |
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| Authors: | E Babu V K Gopalakrishnan I Navis Paul Sriganth R Gopalakrishnan D Sakthisekaran |
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| Institution: | (1) Department of Medical Biochemistry, University of Madras, Taramani Campus, 600 113 Madras, India |
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| Abstract: | The objective of this study was to assess the therapeutic advantage of glutathione ester along with cisplatin. Comparisons were made with renal reduced glutathione, enzymatic antioxidants, and lipid peroxidation levels. Cisplatin caused differential toxic effects on renal antioxidants and lipid peroxidation. However administration of glutathione ester modulates the toxic effects of cisplatin observed in renal antioxidants and lipid peroxidation. The finding that glutathione ester co-administration along with cisplatin is more effective and advantageous in protecting against the nephrotoxicity of cisplatin when it was given alone. |
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| Keywords: | cisplatin glutathione ester reduced glutathione antioxidants lipid peroxidation nephrotoxicity |
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