Rapid genomic-scale analysis of Escherichia coli O104:H4 by using high-resolution alternative methods to next-generation sequencing |
| |
Authors: | Jackson Scott A Kotewicz Michael L Patel Isha R Lacher David W Gangiredla Jayanthi Elkins Christopher A |
| |
Affiliation: | Center for Food Safety and Applied Nutrition, United States Food and Drug Administration, Laurel, MD, USA. |
| |
Abstract: | Two technologies, involving DNA microarray and optical mapping, were used to quickly assess gene content and genomic architecture of recent emergent Escherichia coli O104:H4 and related strains. In real-time outbreak investigations, these technologies can provide congruent perspectives on strain, serotype, and pathotype relationships. Our data demonstrated clear discrimination between clinically, temporally, and geographically distinct O104:H4 isolates and rapid characterization of strain differences. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|