Synthesis and neurite growth evaluation of new analogues of honokiol, a neolignan with potent neurotrophic activity |
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| Authors: | Praveen Kumar Vemula Gajendra Reddy R Vo Duc Duy Chakravarty Sumana Chandrasekhar Srivari Grée René |
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| Affiliation: | Division of Natural Product Chemistry, Indian Institute of Chemical Technology, Hyderabad 500 607, India. |
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| Abstract: | A versatile synthetic route is reported towards the preparation of new analogues for potent neurotrophic agent biaryl-type lignan honokiol. A focused 24-membered library of derivatives containing five different groups at 5'-position of honokiol has been prepared in fair to good overall yields. Compared to the natural product, or to analogues with a short alkyl chain in this position, these new derivatives have lost most of the neurotrophic activity. |
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