Bioorthogonal noncovalent chemistry: Fluorous phases in chemical biology |
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Authors: | Yoder Nicholas C Yüksel Deniz Dafik Laila Kumar Krishna |
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Affiliation: | Department of Chemistry, Tufts University, Medford, MA 02155, USA. |
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Abstract: | Chemical entities designed to noncovalently interact with predetermined partners have fashioned a new paradigm in chemical biology. Fluorocarbons are extremely promising as supramolecular synthons toward these objectives. Bioorthogonal noncovalent interactions provide a way to modulate self-assembled systems in environments where such control has hitherto not been possible. Fluorocarbons have now found applications in self-assembly as well as proteomics, biomolecule purification and in the creation of microarray platforms. Other self-assembly motifs with similar attributes might be exploited using the same general approach. |
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