Myelopeptide MP-5 and fluorescent derivatives: Synthesis and biological activity |
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| Authors: | L. A. Fonina A. A. Az’muko V. N. Kalikhevich M. L. Lewit Z. A. Ardemasova S. A. Gur’yanov R. G. Belevskaya M. A. Efremov E. M. Treshchalina A. A. Mikhailova |
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| Affiliation: | L. A. Fonina, A. A. Az’muko, V. N. Kalikhevich, M. L. Lewit, Z. A. Ardemasova, S. A. Gur’yanov, R. G. Belevskaya, M. A. Efremov, E. M. Treshchalina and A. A. Mikhailova |
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| Abstract: | The Val-Val-Tyr-Pro-Asp bone marrow peptide (MP-5) and its analogue (MP-5-Lys) were synthesized. Fluorescent derivatives, Ftc-MP-5 and MP-5-Lys(Ftc), were prepared. The iological activity of MP-5 and MP-5-Lys was studied in vitro and in vivo. The MP-5 peptide caused 60–84% inhibition of growth of the following mouse cancers: lymphatic leukemia P388, melanoma B-16, and cervical carcinoma CUC-5. These peptides also restored functional activity of T-lymphocytes that was inhibited by metabolic products of the HL-60 leukemic cell line. MP-5-Lys(Ftc) was shown to preserve the functional properties of MP-5 towards T-lymphocytes, but Ftc-MP-5 was practically inactive. |
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| Keywords: | myelopeptide MP-5 VVYPD fluorescent analogues synthesis T-lymphocytes proliferative response antitumor activity |
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