Kinetic model for membrane transport. 1. Effects of membrane volume and partitioning kinetics |
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| Authors: | K Makino H Ohshima T Kondo |
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| Affiliation: | Faculty of Pharmaceutical Sciences, Science University of Tokyo, Japan. |
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| Abstract: | Equations for the transport of solutes through a membrane are derived, taking into account both the membrane volume and the partitioning kinetics, and have been found to involve two rate constants for solute transport, namely, those corresponding to solute transport from the solution to the membrane (k1) and from the membrane to the solution (k2). The time course followed before partitioning equilibrium has been attained, which is usually ignored, is shown to depend strongly on the relative magnitudes of k1 and k2. |
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