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Amphiphilic dendrimeric peptides as model non-sequential pharmacophores with antimicrobial properties
Authors:Janiszewska Jolanta  Urbanczyk-Lipkowska Zofia
Institution:Industrial Chemistry Research Institute, Polish Academy of Sciences, Warsaw, Poland.
Abstract:A concept of application of dendrimer chemistry for construction of 'non-sequential pharmacophore', mimicking active conformation of linear antimicrobial peptides, is introduced. It resulted in the synthesis of a family of low- molecular-weight basic peptide dendrimers with antimicrobial properties against Staphylococcus aureus (Gram-positive), Escherichia coli (Gram-negative) and Candida albicans.
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