RXR-2, a member of the retinoid x receptor family in Schistosoma mansoni. |
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| Authors: | W J Freebern E G Niles P T LoVerde |
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| Affiliation: | Department of Microbiology, and Center for Microbial Pathogenesis, School of Medicine and Biomedical Sciences, State University of New York, Buffalo, NY 14214, USA. |
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| Abstract: | A cDNA encoding a second full-length member of the Schistosoma mansoni RXR family (SmRXR-2) was identified. The nucleotide sequence of SmRXR-2 translates into a protein of 784 amino acids with a pI of 7.63 and an approximate mass of 78kDa making it the largest reported RXR to date. Phylogenetic tree analysis provides evidence that SmRXR-2 is the most ancient full-length RXR identified. SmRXR-2 exhibits unique sequence features compared with other RXRs. RT-PCR results demonstrate that the SmRXR-2 gene is constitutively expressed and thus must play multiple roles throughout schistosome development in the vertebrate host. |
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