Genomic representations using concatenates of Type IIB restriction endonuclease digestion fragments |
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| Authors: | Tengs Torstein LaFramboise Thomas Den Robert B Hayes David N Zhang Jianhua DebRoy Saikat Gentleman Robert C O'Neill Keith Birren Bruce Meyerson Matthew |
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| Affiliation: | Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA. |
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| Abstract: | We have developed a method for genomic representation using Type IIB restriction endonucleases. Representation by concatenation of restriction digests, or RECORD, is an approach to sample the fragments generated by cleavage with these enzymes. Here, we show that the RECORD libraries may be used for digital karyotyping and for pathogen identification by computational subtraction. |
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