Non-viral eNOS gene delivery and transfection with stents for the treatment of restenosis |
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| Authors: | Luis A Brito Saradha Chandrasekhar Steven R Little Mansoor M Amiji |
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| Institution: | (1) Department of Pharmaceutical Sciences, Northeastern University, 02115 Boston, MA, USA;(2) Department of Chemical Engineering, University of Pittsburgh, 15261 Pittsburgh, PA, USA |
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| Abstract: | Background In this study, we have examined local non-viral gene delivery, transfection, and therapeutic efficacy of endothelial nitric
oxide synthase (eNOS) encoding plasmid DNA administered using coated stents in a rabbit iliac artery restenosis model. |
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