Cyclooxygenase-2 Immunoreactivity and Protein Level in the Gerbil Hippocampus During Normal Aging |
| |
| Authors: | Choong Hyun Lee Ki-Yeon Yoo Jung Hoon Choi Ok Kyu Park In Koo Hwang Il-Jun Kang Moo-Ho Won |
| |
| Institution: | (1) Department of Anatomy and Neurobiology, and Institute of Neurodegeneration and Neuroregeneration, College of Medicine, Hallym University, Chuncheon, 200-702, South Korea;(2) Department of Anatomy and Cell Biology, College of Veterinary Medicine and BK21 Program for Veterinary Science, Seoul National University, Seoul, 151-742, South Korea;(3) Department of Food Science and Nutrition, Hallym University, Chuncheon, 200-702, South Korea; |
| |
| Abstract: | Cyclooxygenases-2 (COX-2) is not only related to inflammation but also plays critical roles in brain development and synaptic
signaling. In the present study, we investigated age-related changes in COX-2 immunoreactivity and protein levels in the gerbil
hippocampus. In the hippocampal CA1 region (CA1) and dentate gyrus (DG), weak COX-2 immunoreactivity was observed at postnatal
month 1 (PM 1), and COX-2 immunoreactivity was markedly increased at PM 18 and 24. In the CA2/3, COX-2 immunoreactivity was
strong at PM 1. COX-2 immunoreactivities in the PM 3, 6 and 12 groups were decreased compared to that in the PM 1 group, and
it was increased at PM 18 and 24. In addition, age-related changes in COX-2 levels were similar with immunohistochemical results
in the CA2/3. These results suggest that COX-2 immunoreactivity and levels were high in the hippocampus of aged gerbils. |
| |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ |
|
