Lowering the apoptotic threshold in colorectal cancer cells by targeting mitochondria |
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| Authors: | Jayesh Sagar Kevin Sales Jan-Willem Taanman Sas Dijk Marc Winslet |
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| Institution: | (1) Division of Surgery and Interventional Science, University College London, Gower Street, WC1E 6BT London, UK;(2) Academic Department of Surgery, Royal Free & University College Medical School, Pond Street, NW3 2QG London, UK;(3) Department of Clinical Neuroscience, Royal Free & University College Medical School, Pond Street, NW3 2QG London, UK |
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| Abstract: | Background Colorectal cancer is the third most-common cancer and the second most-common cause of cancer related death in UK. Although
chemotherapy plays significant role in the treatment of colorectal cancer, morbidity and mortality due to drug resistance
and cancer metastasis are yet to be eliminated. Recently, doxycycline has been reported to have cytotoxic and anti-proliferating
properties in various cancer cells. In this study, whether doxycycline was apoptosis threshold lowering agent in colorectal
cancer cells by targeting mitochondria was answered. |
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