Matrix metalloproteinases in the cervical mucus plug in relation to gestational age,plug compartment,and preterm labor |
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| Authors: | Naja Becher Merete Hein Carl C Danielsen Niels Uldbjerg |
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| Affiliation: | (1) Department of Obstetrics and Gynecology, Aarhus University Hospital Skejby, DK-8200 Aarhus N, Denmark;(2) Department of Connective Tissue Biology, Institute of Anatomy, University of Aarhus, DK-8000 Aarhus C, Denmark |
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| Abstract: | Background High concentrations of matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) have been identified in the cervical mucus plug (CMP) at term of pregnancy. Their physiological and pathophysiological implications, however, remain to be elucidated, and CMPs from preterm labor have never been examined. This study was therefore conducted to describe the concentrations of MMP-2, TIMP-1, MMP-8 and MMP-9 in the CMP in relation to gestational age, IL-8 as an indicator of inflammation, compartment of the CMP, and preterm labor. |
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