Nuclear translocation of insulin receptor substrate-1 by the insulin receptor in mouse embryo fibroblasts |
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Authors: | Wu An Sciacca Laura Baserga Renato |
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Institution: | Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA. |
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Abstract: | Translocation of the insulin receptor substrate-1 (IRS-1) to the nuclei has been reported to occur in cells stimulated by insulin-like growth factor-1 (IGF-I) or expressing certain viral and cellular oncogenes. We show here that insulin can also induce nuclear translocation of IRS-1 in mouse embryo fibroblasts (MEF), that do not express the type 1 insulin-like growth factor receptor (IGF-IR). Only the A isoform of the insulin receptor (IR) can induce IRS-1 nuclear translocation, which is significant when the receptor is over-expressed. At physiological receptor levels, translocation occurs only in a fraction of cells, and only at high concentrations of ligand. |
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