Semicontinuous penicillin production by two Penicillium chrysogenum strains immobilized in calcium alginate beads |
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Authors: | Abdel-Halim Mahmoud Mohammed El-Sayed Hans Jürgen Rehm |
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Affiliation: | (1) Institut für Mikrobiologie der Universität Münster, Corrensstr. 3, 44000 Münster, Germany;(2) Present address: Department of Microbiology, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt |
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Abstract: | Summary The growth rates of immobilized Penicillium chrysogenum strains are important in their application to semicontinuous penicillin production. Immobilized P. chrysogenum strains produced about 10–15% less biomass but about 1–2 times more penicillin than free suspended mycelia.In a chemically defined medium an industrial P. chrysogenum strain, S1, produced about 10–12 times more penicillin than strain ATCC 12690. In a complex medium the immobilized P. chrysogenum S1 produced about 12% penicillin more than in shaken cultures. In bubble column fermentations, penicillin production was 163% higher in the complex medium than in the chemically defined medium. |
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