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Cystine uptake by rat jejunal brushborder membrane vesicles |
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| Authors: | Božena Ožegović Pamela D. McNamara Stanton Segal |
| Affiliation: | (1) Division of Biochemical Development and Molecular Diseases, Children's Hospital of Philadelphia, Philadelphia, PA, USA;(2) Departments of Pediatrics and Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, USA;(3) Present address: Faculty of Pharmacy and Biochemistry, University of Zagreb, Zagreb, Yugoslavia |
| Abstract: | The presence of a sodium-stimulated, saturable uptake process for L-cystine is described in brushborder membrane vesicles isolated from rat jejunal mucosa. Concentration-dependence studies indicate the presence of a single transport system for cystine withKm=0.053 mM andVmax=0.633 nmol/mg/15 s. Lysine completely inhibits the uptake of cystine. |
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