| Dkk-1在肿瘤中的研究进展 |
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| 引用本文： | 赵衡,敖军平,李锦军. Dkk-1在肿瘤中的研究进展[J]. 生命科学, 2010, 0(9): 869-872 |
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| 作者姓名： | 赵衡 敖军平 李锦军 |
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| 作者单位： | 上海交通大学肿瘤研究所癌基因及相关基因国家重点实验室,上海200032 |
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| 基金项目： | 国家自然科学基金项目（30731160004）; 国家重点基础研究发展计划（“973”项目）（2009CB521803） |
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| 摘 要： | DKK-1是一种分泌型糖蛋白,通过结合细胞表面受体LRP5/6、Kremen1/2在Wnt通路中起负调控作用。Dkk-1的表达受p53、MYCN、β-catenin等基因调控。Dkk-1在细胞内的异位表达能抑制多种肿瘤细胞的增殖,但有时能在促凋亡因子存在时诱发凋亡。Dkk-1在一些肿瘤中低表达,而在另一些肿瘤中高表达。Dkk-1在不同肿瘤的发生、发展以及转移这几个阶段中的表达和功能表现出复杂多重的差异。该文就Dkk-1在肿瘤中表达和功能的研究进展作一综述。
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| 关 键 词： | Dkk-1 肿瘤 Wnt通路 |
Recent progress of Dkk-1 in tumors |
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| ZHAO Heng,AO Jun-ping,LI Jin-jun. Recent progress of Dkk-1 in tumors[J]. Chinese Bulletin of Life Sciences, 2010, 0(9): 869-872 |
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| Authors: | ZHAO Heng AO Jun-ping LI Jin-jun |
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| Affiliation: | (State Key Laboratory of Oncogenes and Related Genes,Shanghai Cancer Institute,Shanghai Jiao Tong University,Shanghai 200032,China) |
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| Abstract: | DKK-1 is a secretary glycoprotein,which negatively regulates Wnt pathway through binding to surface receptors LRP5/6 and Kremen 1/2. The expression of Dkk-1 is regulated by p53,MYCN,β-catenin,etc. Ectopic expression of Dkk-1 could inhibit cell proliferation,or induce apoptosis with apoptosis enhancing factors. Dkk-1 low-expressed in many tumors,but overexpressed in others. Growing evidences show that Dkk-1 play complex and different roles in tumorigenesis,tumor progression and metastasis of different cancers. We herein review the recent progress in the expression and function of Dkk-1 in tumors. |
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| Keywords: | Dickkopf-1 tumorigenesis Wnt pathway |
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