病毒的细胞进入研究进展及其应用前景

病毒感染的初期事件包括病毒与细胞表面受体的相互作用和进入细胞的过程,而病毒的宿主细胞专一性很大程度上取决于这一阶段的专一识别特征和特殊要求。人乳头状瘤病毒、人免疫缺陷病毒和单纯疱疹病毒是感染人类的几种常见病原物,该文简要综述和讨论了与人体健康关系密切的这三种重要病毒表面的蛋白组分、宿主细胞表面受体及其相互作用和病毒的细胞进入的研究进展,以及在以病毒的细胞进入过程为靶点的抗病毒药物研发中的应用前景。

Progress of the research on viral cell entry and its application

Initial events of virus infection include interaction of viruses with cell surface components and viral cell entry.Cell tropism of viruses may greatly rely on specific binding of viral ligands to cell receptors during the interactions and some special requirements.Human papilloma virus（HPV）,herpes simplex virus（HSV） and human immunodeficiency virus（HIV） are usual human pathogens.The purposes of this review are to summarize available information about the viral ligands,cell surface receptors and their interactions during viral cell attachment and cell entry for the three kinds of viruses and to discuss future application in the research and development of new antiviral drugs targeting viral cell entry.