骨髓间充质干细胞在组织损伤局部微环境中的调节作用

骨髓间充质干细胞(mesenchymal stem cells,MSCs)是一种具有自我增殖和多向分化潜能的细胞,植入体内后对损伤组织具有一定的修复作用,研究发现MSCs在体内的分化效率极低(不足10%),故仅用其分化能力不能完全解释它良好的修复效能。新近研究表明,MSCs可通过旁分泌途径调节损伤局部的微环境,从而促进受损组织的修复,提示这种微环境的调节较其自身分化更具有临床意义。该文对MSCs在组织损伤局部微环境中的调节作用做一简要概述,为MSCs更广阔地应用于医学领域提供理论基础。

Regulation effects of the bone marrow-derived mesenchymal stem cells in local microenvironment of injury tissue

Bone marrow-derived mesenchymal stem cells（MSCs） are a kind of self-renewal and multipotential cells,and have restoration effects on injured tissue following transplantation in vivo. However,the low differentiation efficiency（less than 10%） of MSCs in vivo could not explain its recovery function in theory. Recent studies have reported that MSCs can regulate the local injury microenvironment via paracrinal pathways and facilitate the restore of impaired tissues,indicating that the microenvironment regulation of MSCs plays more important role than its differentiation in clinical recovery. The current paper reviewed the regulatory effects of MSCs in local microenvironment of damaged tissue,providing theoretical basis for broadly clinical application of MSCs transplantation therapy.