| 分子伴侣介导的细胞自噬作用机制及其功能 |
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| 引用本文： | 席兴宇. 分子伴侣介导的细胞自噬作用机制及其功能[J]. 生命科学, 2010, 0(10): 991-994 |
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| 作者姓名： | 席兴宇 |
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| 作者单位： | 新乡学院教育科学系,新乡453007 |
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| 摘 要： | 分子伴侣介导的细胞自噬(chaperone-mediated autophagy,CMA)是通过溶酶体途径选择性降解胞质中带KFERQ-序列的蛋白质。CMA不仅为细胞在持久饥饿状态下提供能量,还在氧化性损伤保护、维持细胞内环境稳态等方面发挥作用。此外,CMA功能障碍还与某些疾病的发生有关。该文简要综述了这方面的研究进展。
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| 关 键 词： | 分子伴侣 自噬 热休克蛋白70 溶酶体 |
The mechanisms and functions of chaperone-mediated autophagy |
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| Affiliation: | XI Xing-zi(College of Education Science,Xinxiang University,Xinxiang 453007,China) |
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| Abstract: | Chaperone-mediated autophagy（CMA） is selective lysosomal pathway for the degradation of cytosolic proteins containing the KFERQ-related motif.CMA not only provides energy for cells during prolonged starvation,but also plays key roles in oxidative stress and cellular homeostasis.In addition,CMA dysfunction is of relevance in certain pathologies.This paper summarizes the recent research progress in CMA. |
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| Keywords: | chaperone autophagy heat shock cognate protein 70 lysosome |
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