Design,synthesis and SAR of substituted indoles as selective TrkA inhibitors期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Design,synthesis and SAR of substituted indoles as selective TrkA inhibitors

Authors:	Danielle M. Hurzy Darrell A. Henze Tamara D. Cabalu Kartik Narayan Amanda Heller Andrew J. Cooke

Affiliation:	1. Department of Medicinal Chemistry, MRL, Merck & Co., Inc., 770 Sumneytown Pike, West Point, PA 19486, USA;2. Department of Pain Research, MRL, Merck & Co., Inc., 770 Sumneytown Pike, West Point, PA 19486, USA;3. Department of Drug Metabolism, MRL, Merck & Co., Inc., 770 Sumneytown Pike, West Point, PA 19486, USA;4. Analytical Process and Technology, Sanofi Pasteur, Discovery Drive, Swiftwater, PA 18370, USA;5. Scientific Operations, Lab Connect, LLC., 605 First Avenue, Ste. 300, Seattle, WA 98104, USA

Abstract:	A series of substituted indoles were examined as selective inhibitors of tropomyosin-related kinase receptor A (TrkA), a therapeutic target for the treatment of pain. An SAR optimization campaign based on ALIS screening lead compound 1 is reported.

Keywords:	TrkA Pain Indoles
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