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Flex-nucleoside analogues – Novel therapeutics against filoviruses |
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| Authors: | Mary K Yates Mithun R Raje Payel Chatterjee Christina F Spiropoulou Sina Bavari Mike Flint Veronica Soloveva Katherine L Seley-Radtke |
| Institution: | 1. Department of Chemistry and Biochemistry, University of Maryland Baltimore County, Baltimore, MD 21250, United States;2. Viral Special Pathogens Branch, Centers for Disease Control and Prevention, Atlanta, GA 30329, United States;3. US Army Medical Research Institute, Frederick, MD 21702, United States |
| Abstract: | Fleximers, a novel type of flexible nucleoside that have garnered attention due to their unprecedented activity against human coronaviruses, have now exhibited highly promising levels of activity against filoviruses. The Flex-nucleoside was the most potent against recombinant Ebola virus in Huh7 cells with an EC50 = 2 μM, while the McGuigan prodrug was most active against Sudan virus-infected HeLa cells with an EC50 of 7 μM. |
| Keywords: | Nucleoside Filovirus Ebola Antiviral Fleximers |
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