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Interrogation of Functional Cell-Surface Markers Identifies CD151 Dependency in High-Grade Serous Ovarian Cancer
Authors:Mauricio Medrano  Laudine Communal  Kevin R. Brown  Marcin Iwanicki  Josee Normand  Joshua Paterson  Fabrice Sircoulomb  Paul Krzyzanowski  Marian Novak  Sasha A. Doodnauth  Fernando Suarez Saiz  Jane Cullis  Rima Al-awar  Benjamin G. Neel  John McPherson  Ronny Drapkin  Laurie Ailles  Anne-Marie Mes-Massons  Robert Rottapel
Affiliation:1. Princess Margaret Cancer Center, University Health Network, Toronto, ON M5G 1L7, Canada;2. Department of Medical Biophysics, University of Toronto, Toronto, ON M5G 1L7, Canada;3. Department of Medicine, University of Toronto, Toronto, ON M5G 2C4, Canada;4. Department of Immunology, University of Toronto, Toronto, ON M5S 1A8, Canada;5. Division of Rheumatology, St. Michael’s Hospital, Toronto, ON M5B 1W8, Canada;6. Centre de Recherche du Centre Hospitalier de l’Université de Montréal (CRCHUM), Montreal, QC H2X 0A9, Canada;7. Institut du Cancer de Montréal, Montréal, QC H2X 0A9, Canada;8. Département de Médecine, Université de Montréal, Montreal, QC H3T 1J4, Canada;9. Banting and Best Department of Medical Research, Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON M5S 3E1, Canada;10. Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA;11. Ontario Institute for Cancer Research, MaRS Centre, Toronto, ON M5G 1L7, Canada;12. Department of Medical Oncology, Center for Molecular Oncologic Pathology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA;13. Ovarian Cancer Research Center, Department of Obstetrics and Gynecology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA;14. Department of Biochemistry and Molecular Pharmacology, New York University School of Medicine, New York, NY 10016, USA;15. Laura and Isaac Perlmutter Cancer Centre, NYU Langone Medical Center, New York, NY 10016, USA
Abstract:
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  • Keywords:high-grade serous ovarian cancer  mesenchymal subtype  RNAi screen  cell-surface  CD151
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