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Salivary calculi microbiota: new insights into microbial networks and pathogens reservoir |
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| Authors: | Roberta De Grandi Pasquale Capaccio Alessandro Bidossi Marta Bottagisio Lorenzo Drago Sara Torretta Lorenzo Pignataro Elena De Vecchi |
| Affiliation: | 1. Laboratory of Clinical Chemistry and Microbiology, IRCCS Orthopedic Institute Galeazzi, via R. Galeazzi 4, 20161 Milan, Italy;2. ENT Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, via Commenda 10, 20122 Milan, Italy;3. Department of Biomedical, Surgical, and Odontoiatric Sciences, University of Milan, via Commenda 10, 20122 Milan, Italy;4. Department of Clinical Sciences and Community Health, University of Milan, via Mangiagalli 31, 20133 Milan, Italy;5. Department of Clinical Sciences and Community Health, University of Milan, via F. Sforza 35, 20122 Milan, Italy |
| Abstract: | Sialolithiasis represents the most common disorders of salivary glands in middle-aged patients. It has been hypothesized that the retrograde migration of bacteria from the oral cavity to gland ducts may facilitate the formation of stones. Thus, in the present study, a microbiome characterization of salivary calculi was performed to evaluate the abundance and the potential correlations between microorganisms constituting the salivary calculi microbiota. Our data supported the presence of a core microbiota of sialoliths constituted principally by Streptococcus spp., Fusobacterium spp. and Eikenella spp., along with the presence of important pathogens commonly involved in infective sialoadenitis. |
| Keywords: | Salivary calculi Sialolithiasis Microbiota Microbial network Sialoadenitis Biofilm |
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