首页 | 本学科首页   官方微博 | 高级检索  
     


Virtual screen to NMR (VS2NMR): Discovery of fragment hits for the CBP bromodomain
Authors:Dimitrios Spiliotopoulos  Jian Zhu  Eike-Christian Wamhoff  Nicholas Deerain  Jean-Rémy Marchand  Jonas Aretz  Christoph Rademacher  Amedeo Caflisch
Affiliation:1. Department of Biochemistry, University of Zürich, Winterthurerstrasse 190, CH-8057 Zürich, Switzerland;2. Department of Biomolecular Systems, Max Planck Institute of Colloids and Interfaces, Am Mühlenberg 1, 14424 Potsdam, Germany;3. Institute of Chemistry and Biochemistry, Department of Biology, Chemistry, and Pharmacy, Freie Universität Berlin, Takustraße 3, 14195 Berlin, Germany
Abstract:
Keywords:Alpha  amplified luminescent proximity homogeneous assay  ATAD2  ATAD2 ATPase family, AAA domain containing 2  BAZ2A  bromodomain adjacent to zinc finger domain protein 2A  BAZ2B  bromodomain adjacent to zinc finger domain protein 2B  BRPF1  bromodomain and PHD finger (BRPF) containing protein 1  CBP  CREB-binding protein  CREB  cyclic-AMP response element binding protein  CSPs  chemical shift perturbations  DMSO  dimethyl sulfoxide  DSF  differential scanning fluorimetry  EP300  adenoviral E1A binding protein  HAC  heavy atom count  Kac  N-ε-acetyllysine  LE  ligand efficiency  NMR  nuclear magnetic resonance  qPCR  quantitative PCR polymerase chain reaction  STD  saturation transfer difference  VS2NMR  Virtual Screen to NMR  Docking  Virtual screening  NMR spectroscopy  Epigenetics  X-ray crystallography  Bromodomain inhibitors
本文献已被 ScienceDirect 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号