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3D genomics imposes evolution of the domain model of eukaryotic genome organization

Authors:	Sergey?V.?Razin,Yegor?S.?Vassetzky author-information" > author-information__contact u-icon-before" > mailto:vassetzky@igr.fr" title=" vassetzky@igr.fr" itemprop=" email" data-track=" click" data-track-action=" Email author" data-track-label=" " >Email author

Affiliation:	1.Institute of Gene Biology RAS,Moscow,Russia;2.LIA1066 “French-Russian Cancer Research Laboratory”,Villejuif,France;3.Lomonosov Moscow State University,Moscow,Russia;4.CNRS UMR8126,Université Paris Sud Paris Saclay, Institut Gustave Roussy,Villejuif,France

Abstract:	The hypothesis that the genome is composed of a patchwork of structural and functional domains (units) that may be either active or repressed was proposed almost 30 years ago. Here, we examine the evolution of the domain model of eukaryotic genome organization in view of the expansion of genome-scale techniques in the twenty-first century that have provided us with a wealth of information on genome organization, folding, and functioning.

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