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Synthesis and biological evaluation of kresoxim-methyl analogues as novel inhibitors of hypoxia-inducible factor (HIF)-1 accumulation in cancer cells
Authors:Sanghyuck Lee  Oh Seok Kwon  Chang-Soo Lee  Misun Won  Hyun Seung Ban  Choon Sup Ra
Institution:1. School of Chemistry and Biochemistry, Yeungnam University, 280 Daehak-Ro, Gyeongsan-si, Gyeongbuk 38541, Republic of Korea;2. Hazards Monitoring Bionano Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon 34141, Republic of Korea;3. Personalized Genomic Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon 34141, Republic of Korea;4. Metabolic Regulation Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon 34141, Republic of Korea;5. Biomolecular Science, University of Science and Technology, Daejeon 34113, Republic of Korea
Abstract:
Keywords:Kresoxim analogues  Cancer  Hypoxia-inducible factor-1 inhibitor  Mitochondrial respiration
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