A minimalistic tetrapeptide amphiphile scaffold for transmembrane pores with a preference for sodium |
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Authors: | Debajyoti Basak Sucheta Sridhar Amal K Bera Nandita Madhavan |
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Institution: | 1. Department of Chemistry, Indian Institute of Technology Madras, Chennai 600036, India;2. Department of Bio-Technology, Indian Institute of Technology Madras, Chennai 600036, India;3. Department of Chemistry, Indian Institute of Technology Bombay, Mumbai 400076, India |
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Abstract: | Synthetic channels or pores that are easy to synthesize, stable and cation-selective are extremely attractive for the development of therapeutics and materials. Herein, we report a pore developed from a small tetrapeptide scaffold that shows a preference for sodium over lithium/potassium. The sodium selectivity is attributed to the appended oligoether tail at the C-terminus. A peptide dimer is proposed as the predominant cation-transporting pore. Such pyridine containing stable pores can be potentially utilized for the pH modulated ion transport. |
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Keywords: | Pores Peptides Amphiphiles Sodium transport Ion channels |
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