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Mutations that Allow SIR2 Orthologs to Function in a NAD+-Depleted Environment |
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| Authors: | Caitlin R. Ondracek Vincent Frappier Alison E. Ringel Cynthia Wolberger Leonard Guarente |
| Affiliation: | 1. Glenn Center for the Science of Aging, Department of Biology, Koch Institute, MIT, Cambridge, MA 02139, USA;2. Keating Laboratory, Department of Biology, MIT, Cambridge, MA 02139, USA;3. Department of Biophysics and Biophysical Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA |
| Abstract: |  |
| Keywords: | Sir2 SIRT1 aging adaptive mutations predictive protein modeling kinetic analyses yeast replicative lifespan |
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