| 与衰老相关的母源性生育力下降 |
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| 引用本文： | 崔龙波,孙方臻.与衰老相关的母源性生育力下降[J].动物学杂志,2005,40(1):114-118. |
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| 作者姓名： | 崔龙波 孙方臻 |
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| 作者单位： | 烟台大学生物化学系,烟台,264005;中国科学院遗传与发育生物学研究所,北京,100080 |
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| 基金项目： | 国家重点基础研究发展计划(973计划) |
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| 摘 要： | 老龄妇女与雌性动物生育力下降和丧失的原因包括卵母细胞库减少以及卵巢、输卵管和子宫的结构和功能障碍，但由减数分裂错误引起的卵母细胞质量下降是与衰老相关的母源性生育力下降的主要原因之一。卵母细胞的减数分裂错误主要表现为非整倍性和染色单体提前分离。本文主要综述了影响母源性生育力的各种因素、老龄动物卵母细胞减数分裂错误的原因、纺锤体和染色体改变的机制以及小鼠作为研究妇女年龄与生育力相互关系的动物模型等问题。
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| 关 键 词： | 年龄 生育力 卵母细胞 |
| 文章编号： | 0250-3263(2005)01-114-05 |
Ageing-related Decline in Female Fertility |
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| Abstract: | The decline and loss of female fertility in human and animals is likely due to the diminishing pool of ovarian follicles and structural and functional abnormality of ovary,oviduct and uterus.However,poor oocyte quality derived from meiotic errors is one of the major causes for the ageing-related decline in female fertility.The meiotic errors of the oocytes affect female fertility by causing abnormal spindle assembly,chromosome aneuploidy and premature chromatid segregation.This paper reviews various factors that cause oocyte abnormality in ageing animals and the use of mouse as an animal model for studying the relationship between woman age and fertility. |
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| Keywords: | Age Fertility Oocyte |
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