泌尿生殖道支原体培养及耐药性差异分析

目的检测本地区人群泌尿生殖道溶脲脲原体（Uu）和人型支原体（Mh）感染的发生率；分析其对9种抗生素的药物敏感性差异，用以指导临床的抗生素治疗。方法采用法国生物梅里埃Mycoplasma IST2试剂盒对支原体进行分离培养鉴定和药物敏感性试验；分析2008—2013年本地区支原体感染患者耐药性的差异。结果在本地区8168例疑似NGU的患者中检出支原体2564例，阳性检出率为31．39％，其中仅uu感染的患者1833例（22．44％），Uu和Mh混合感染的患者623例（7．63％），仅Mh感染的患者108例（1．32％）。仅uu感染的患者对PRI、JOS、DOT、TET、CLA、AZI、ERY、OFL和CIP九种抗生素的敏感率分别为99．8％、99．4％、96．3％、91．9％、90．O％、89．7％、69．7％、4．O％和0．5％；Uu和Mh混合感染的患者对9种抗生素的敏感率分别为96．3％、96．1％、94．8％、79．5％、12．0％、11．7％、1．4％、1．0％和0．3％；仅Mh感染的患者对9种抗生素的敏感率分别为100％、100％、100％、90．7％、0％、0％、O％、14．8％和13．9％。结论本地区泌尿生殖道支原体感染以Uu感染最为常见，Uu和Mh混合感染次之，Mh感染最为少见；对支原体的抗生素治疗首选PRI、JOS、DOT；TET、AZI、CLA可适当使用，而ERY、OFL、CIP则不宜选用。

Culture of mycoplasma from genitourinary tract and analysis of difference in drug resistance

Objective To detect the infection rate of Ureaplasma urealyticum （Uu） and Mycoplasma hominis （Mh） from genitourinary tract among the local people, analyze the difference in drug resistance to 9 antibiotics and guide clinic antibiotic treatments. Methods To identify mycoplasma and test drug susceptibility with the kit of biomerieux Mycoplasma IST2, the difference in drug resistance among the local patients with myeoplasma infection in 2008 -2013 were analyzed. Results Among the 8 168 patients who were doubted NGU, 2 564 of them were de- tected with mycoplasma infection. The positive detection rate was 31.39% , including 1 833 cases with Uu infection （22.44%）, 623 cases with Uu and Mh mixed infection （7.63%） and 108 cases with Mh infection （1.23%）. The sensitivity rates of Uu to PRI, dOS, DOT, TET, CLA, AZI, ERY, OFL and CIP were 99.8 %, 99.4%, 96.3 %, 91.9% ,90.0% ,89.7% ,69.7% ,4.0% and 0.5%, respectively. The sensitivity rates of Uu and Mh were 96. 3% ,96.1% ,94.8% ,79.5%, 12.0%, 11.7%, 1.4%, 1.0% and 0.3% ,respectively. The sensitivity rates of Mh were 100% ,100% ,100% ,90.7% ,0% ,0% ,0% ,14.8% and 13.9% ,respectively. Conclusion Among myco- plasma infections, Uu infection ranks first, Uu and Mh mixed infection is next and the Mh infection is the least. In antibiotic treatments for mycoplasma infection, PRI, dOS and DOT may be the first choice, TET, AZI and CLA may be the second choice, while ERY, OFL and CIP may not be chosen.