| BCG对乳腺癌细胞增殖和凋亡的影响 |
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| 引用本文： | 张瑞山,李翔,谢贤鑫,李欢,张腾,马利艳,徐宏,张斌. BCG对乳腺癌细胞增殖和凋亡的影响[J]. 中国微生态学杂志, 2013, 0(12): 1377-1378,1382 |
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| 作者姓名： | 张瑞山 李翔 谢贤鑫 李欢 张腾 马利艳 徐宏 张斌 |
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| 作者单位： | 辽宁省肿瘤医院乳腺外科,辽宁沈阳110042 |
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| 基金项目： | 国家自然科学基金资助项目（81102029;81172047） |
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| 摘 要： | 目的从细胞增殖和凋亡两方面观察BCG对乳腺癌细胞MDA—MB-231的抑制作用。方法用MTT法检测BCG作用后MDA—MB-231细胞的增殖能力，采用TUNEL法检测凋亡。结果BCG能明显降低MDA-MB-231细胞的增殖代谢活性而抑制其增殖。TUNEL法染色显示BCG可显著增加凋亡细胞。结论BCG不仅能显著抑制MDA—MB-231细胞增殖，还能有效诱导其凋亡。
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| 关 键 词： | BCG 乳腺癌 增殖 凋亡 |
Effect of BCG on proliferation and apoptosis of human mammary cancer cells |
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| ZHANG Rui-shan,LI Xiang,XIE Xian-xin,LI Huan,ZHANG Teng,MA Li-yan,XU Hong,ZHANG Bin. Effect of BCG on proliferation and apoptosis of human mammary cancer cells[J]. Chinese Journal of Microecology, 2013, 0(12): 1377-1378,1382 |
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| Authors: | ZHANG Rui-shan LI Xiang XIE Xian-xin LI Huan ZHANG Teng MA Li-yan XU Hong ZHANG Bin |
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| Affiliation: | Department of Breast Surgery, Liaoning Cancer Hospital and Institute, Shenyang 110042, China |
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| Abstract: | Objective To observe the effect of BCG on proliferation and apoptosis of MDA-MB-231 cells. Methods The proliferation inhibitory effect of BCG on MDA-MB-231 cells was detected by MTT eolormetric assay; MDA-MB- 231 cell apoptosis was observed by TUNEL method. Results BCG obviously inhibited MDA-MB-231 cells prolif- eration. BCG could induce MDA-MB-231 cell apoptosis. There were few apoptosis cells in the control group. Conclusion BCG not only significantly inhibit the proliferation of MDA-MB-231 cells but also induce their apoptosis. |
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| Keywords: | BCG Breast cancer Proliferation Apoptosis |
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