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| 间歇性低氧对大鼠海巴长时程增强电位的影响 | |
| 作者姓名： | Wang XR Ma Q Ding AS Zeng BX Wang FZ |
| 作者单位： | 1. 同济医科大学附属协和医院麻醉学教研室, 2. 军事医学科学院卫生学环境医学研究所 , 3. 军事医 学科学院基础医学研究所, |
| 基金项目： | 国家自然科学基金资助课题(39730190) |
| 摘 要： | 目的：研究间歇性低氧对大鼠海马神经元突触可塑性的影响。方法：大鼠受间歇性低氧处理后,用脑立体定位仪定位,观察海马时程增强电位（LTP）的变化。结果：间歇性低氧大鼠LTP幅值显著低于对照组。结论：间歇性低氯可影响LTP幅值,提示间歇性低氧可能使大鼠海马神经元的突触可塑性发生变化。 |
| 关 键 词： | 间歇性低氧 长时程增强电位 海马 学习记忆 |
| 文章编号： | 1000-6834(2001)01-0018-03 |
| 修稿时间： | 1999年12月10 |
Effects of intermittent hypoxia on long-term potentiation in hippocampal dentate gyrus of rat |
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| Wang XR,Ma Q,Ding AS,Zeng BX,Wang FZ.Effects of intermittent hypoxia on long-term potentiation in hippocampal dentate gyrus of rat[J].Chinese Journal of Applied Physiology,2001,17(1):18-20. | |
| Authors: | Wang X R Ma Q Ding A S Zeng B X Wang F Z |
| Institution: | WANG Xue ren 1,MA Qiang 3,DING Ai shi 2,ZENG Bang xiong 1,WANG Fu zhuang 2 |
| Abstract: | Aim: To investigate the effects of intermittent hypoxia on the hippocampal synaptic plasticity in rat. Methods: The evoked potentials were recorded extracellularly, then the LTP were induced by tetanic stimulation in rat hippocampal dentate gyrus. Results: Compared with control group, the amplitude of LTP was significantly reduced in hippocampus of rat treated with intermittent hypo xia . Conclusions: The present results suggest that the hippocampal synaptic plasticity could be decreased by the treated of intermittent hypoxia. |
| Keywords: | intermitted hypoxia long term potentiation hippocampus |
| 本文献已被 CNKI 维普 万方数据 PubMed 等数据库收录！ | |