Postattachment events associated with viral entry are necessary for induction of interferon-stimulated genes by human cytomegalovirus |
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Authors: | Netterwald James R Jones Thomas R Britt William J Yang Shao-Jun McCrone Ian P Zhu Hua |
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Affiliation: | Department of Microbiology and Molecular Genetics, UMDNJ-New Jersey Medical School, 225 Warren Streeet, Newark, NJ 07101-1709, USA. |
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Abstract: | Utilizing a human cytomegalovirus-specific fusion inhibitor and an antiglycoprotein H antibody, we studied the role of virion fusion in interferon-stimulated gene (ISG) induction. Our results indicate that ISG induction does not occur when virion-mediated, post-high-affinity attachment events are inhibited by either reagent. Thus, virion-mediated postattachment events, such as fusion, are required for ISG induction. |
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