Calcium and inositol 1,4,5-trisphosphate receptors: a complex relationship. |
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Authors: | C W Taylor I C Marshall |
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Affiliation: | Department of Pharmacology, Cambridge, UK. |
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Abstract: | Increases in intracellular free Ca2+ concentration ([Ca2+]i), whether initiated by changes in plasma membrane potential or receptor-stimulated polyphosphoinositide hydrolysis, can be astonishingly complex, often occurring as repetitive Ca2+ spikes and regenerative Ca2+ waves that propagate through the cell and sometimes into neighbouring cells. The key to understanding these complex Ca2+ signals lies in understanding the interactions between the different pools from which Ca2+ can rapidly enter the cytosol and the activities of the various Ca(2+)-transporting systems that reverse the process. |
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