Molecular ablation of ventricular tachycardia after myocardial infarction |
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Authors: | Sasano Tetsuo McDonald Amy D Kikuchi Kan Donahue J Kevin |
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Institution: | Heart and Vascular Research Center, MetroHealth Hospital, Case Western Reserve University School of Medicine, Rammelkamp 653, 2500 MetroHealth Drive, Cleveland, Ohio 44109, USA. |
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Abstract: | Ventricular tachycardia is a common and lethal complication after myocardial infarction. Here we show that focal transfer of a gene encoding a dominant-negative version of the KCNH2 potassium channel (KCNH2-G628S) to the infarct scar border eliminated all ventricular arrhythmias in a porcine model. No proarrhythmia or other negative effects were discernable. Our results demonstrate the potential viability of gene therapy for ablation of ventricular arrhythmias. |
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