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Increased titer and reduced lactate accumulation in recombinant retrovirus production through the down‐regulation of HIF1 and PDK |
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| Authors: | A F Rodrigues M R Guerreiro A S Formas‐Oliveira P Fernandes A‐K Blechert Y Genzel P M Alves W S Hu A S Coroadinha |
| Institution: | 1. Instituto de Biologia Experimental e Tecnológica, Apartado 12, 2781‐901 Oeiras, Portugal;2. Instituto de Tecnologia Química e Biológica, Universidade Nova de Lisboa, Av. da República, 2780‐157 Oeiras, Portugal;3. Max Planck Institute for Dynamics of Complex Technical Systems, Bioprocess Engineering Group, Magdeburg, Germany;4. Department of Chemical Engineering and Materials Science, University of Minnesota, Minneapolis, USA;5. +351 21 4469457+351 21 4421161 |
| Abstract: | |
| Keywords: | glycolysis lactate hypoxia inducible factor 1 pyruvate dehydrogenase kinase recombinant virus functional genomics |