Immunohistochemical localization of basic fibroblast growth factor in ependymal cells of the rat lateral and third ventricles. |
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| Authors: | P Cuevas G Gimenez-Gallego R Martinez-Murillo F Carceller |
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| Affiliation: | Servicio de Histología, Hospital Ramón y Cajal, Madrid, Spain. |
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| Abstract: | The presence of basic fibroblast growth factor (bFGF) in the third and the lateral ventricular ependyma of the rat has been investigated under the light microscope using a polyclonal antibody against bFGF, through the unlabelled peroxidase-antiperoxidase procedure; bFGF-immunoreactivity (bFGF-IR) is observed in the entire ependymal cell layer of ventricles. Also ependymal tanycytes within the inferior portion of the wall and floor of the third ventricle show bFGF-IR. Tanycytic processes are in close contact with hypothalamic capillaries. The present study strongly suggests that brain ependymal bFGF plays unidentified roles unrelated to its angiogenic or mitogenic capacities. |
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