Irradiation increases proteolysis in erythrocyte ghosts: A spin label study |
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Authors: | G Bartosz W Schön G Kraft H Gärtner |
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Institution: | (1) Department of Biophysics, University of Lodz, Lodz, Poland;(2) Experimentalphysik III, Fachbereich Physik, Gesamthochschule Kassel, W-3500 Kassel, Federal Republic of Germany;(3) Gesellschaft für Schwerionenforschung, W-6100 Darmstadt, Federal Republic of Germany |
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Abstract: | Summary X- and gamma-irradiation of human erythrocyte membranes (250–1000 Gy) was found to decrease the ratio of weakly to strongly immobilized signal height of membrane-bound maleimide spin label (Mal-6). Subsequent incubation of spin-labeled membranes at ambient temperature (21 °C) induced a progressive increase in this ratio, faster for membranes irradiated with low doses which was hampered by protease inhibitors. These results demonstrate that ionizing radiation stimulates proteolysis of erythrocyte membrane proteins by membrane-associated proteases. |
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