Total synthesis of the natural antigen involved in the hyperacute rejection response to xenotransplants |
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Authors: | Gege C Kinzy W Schmidt R R |
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Institution: | Faculty of Chemistry, University of Konstanz, Germany. |
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Abstract: | The major glycosphingolipid in pig vascular endothelium is the ceramide pentasaccharide Gal alpha(1 --> 3)Gal beta(1 --> 4)GlcNAc beta(1 --> 3)Gal beta(1 --> 4)Glc beta(1 --> 0)Cer (1), which binds specifically to human anti-Gal antibody and is involved in the hyperacute rejection response in xenotransplantation from pig to man. The synthesis of 1 and its methyl glycoside 2 is described. |
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