Total synthesis of the natural antigen involved in the hyperacute rejection response to xenotransplants |
| |
| Authors: | Gege C Kinzy W Schmidt R R |
| |
| Institution: | Faculty of Chemistry, University of Konstanz, Germany. |
| |
| Abstract: | The major glycosphingolipid in pig vascular endothelium is the ceramide pentasaccharide Gal alpha(1 --> 3)Gal beta(1 --> 4)GlcNAc beta(1 --> 3)Gal beta(1 --> 4)Glc beta(1 --> 0)Cer (1), which binds specifically to human anti-Gal antibody and is involved in the hyperacute rejection response in xenotransplantation from pig to man. The synthesis of 1 and its methyl glycoside 2 is described. |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
|
