Ultra-high redox enzyme signal transduction using highly ordered carbon nanotube array electrodes |
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Authors: | Withey G D Lazareck A D Tzolov M B Yin A Aich P Yeh J I Xu J M |
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Institution: | Division of Engineering, Brown University, Providence, RI 02912, USA. |
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Abstract: | We report on a highly ordered array of carbon nanotubes (CNTs) that serves as a universally direct nanoelectrode interface for redox proteins and provides an efficient conduit for electron transfer. The site-selective, covalent docking of the enzyme glucose oxidase (GO(x)) on the CNT tips is found to have a marked effect on enhancing electron transfer properties, as measured by cyclic voltammetry. A unimolecular electron transfer rate of 1500 s(-1) has been measured for this system, a value exceeding the rate of oxygen reduction by glucose oxidase. Furthermore, the redox enzyme-CNT array conjugate can be utilized as a quantitative, substrate-specific biosensor. |
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