A glucose transporter chimera confers a dominant negative glucose starvation phenotype in Saccharomyces cerevisiae |
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Authors: | Sherwood P W Katic I Sanz P Carlson M |
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Institution: | Department of Genetics and Development, Columbia University, New York, NY 10032, USA. |
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Abstract: | A family of glucose transporters mediates glucose uptake in Saccharomyces cerevisiae. We show that the dominant mutation GSF4-1, which impairs glucose repression of SUC2, results in a nonfunctional chimera of the transporters Hxt1p and Hxt4p. Hxt1/4p inhibits the function of wild-type glucose transporters. Similar mutations may facilitate analysis of the major facilitator superfamily. |
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