乳腺癌p53蛋白过度表达和雌激素受体免疫组化检测及意义

应用免疫组化方法，对３２例乳腺癌组织中肿瘤抑制基因ｐ５３蛋白的表达和雌激素受体的状态分别进行了检测。结果３２例中ｐ５３蛋白阳性１８例，阳性率５６．３％，１８例伴有同侧腋下淋巴结转移者阳性１３例（７２．２％）３而１４例无转移者阳性５例（３５．７％）二组阳性率差异显著（ＰＭＯ．０５）。３２例中雌激素受体阳性１７例，１８例伴转移者阳性８例（４４．４％）；１４例无转移者阳性９例（６４．３％）。结果表明，ｐ５３蛋白的异常表达与乳腺癌的浸润转移有关，结合雌激素受体的检查，可作为临床预后判断一个有价值的标志。

IMMUNOHISTOCHEMICAL STUDY OF P53 PROTEIN OVEREXPRESSION AND ESTROGEN RECEPTOR IN BREAST CANCER

cases of breast cancer were investigated for detection of overexpression of p53 protein and state of estrogen receptor by immunohistochemical method.The results revealed that 18 cases of 32 were p53 protein positive with a positive rate of 56.3%.Among the 18 cases accompanied by axillary lymph-node metastasis 13 were positive(72.2%), while among the 14cases without metastasis 5 were positive(35.7%).The positive rates in two groups were significantly different(P<0.05).In the 32 cases estrogen receptor was positive in 17,among which 8(positie 44.4%) belonged to the 18 cases with metastasis and 9(positive 64.3%) belonged to the 14 cases without metastasis.Our investigation suggests that in breast cancer the overexpression of p53 protein is closely related to proliferation and metastasis.In combination with the determination of estrogen receptor this investigation may serveas a valuable marker for clinical prognosis.