Enantiopure derivatives of 1,2-alkanediols: substrate requirements of lipase B from Candida antarctica |
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| Authors: | Jacobsen E E Hoff B H Anthonsen T |
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| Affiliation: | Department of Chemistry, Norwegian University of Science and Technology, Trondheim, Norway. |
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| Abstract: | Efficient methods for kinetic resolution of 1-phenoxy-2-butanol, 1-phenylmethoxy-2-butanol, and 1-phenoxy-2-pentanol were developed using lipase B from Candida antarctica as catalyst. Resolutions were performed in order to investigate the substrate requirements needed to obtain a high E-value. The effect of the substrate structure on E is different for transesterifications in organic media as compared to hydrolysis. The influence of different acyl donors on the E-value was also investigated. |
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