The effect of inorganic phosphate on calcium influx into rat heart mitochondria |
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Authors: | M Crompton M Hediger E Carafoli |
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Affiliation: | Laboratory of Biochemistry, Swiss Federal Institute of Technology (ETH) Zurich, Switzerland |
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Abstract: | The effect of inorganic phosphate on the accumulation of Ca2+ by heart mitochondria has been reinvestigated. Inorganic phosphate has no effect on the initial rate of Ca2+ uptake supported by respiration on either ascorbate tetramethylenephenylene diamine, pyruvate malate, or glutamate malate, although it does increase the final amount of Ca2+ accumulated; evidence suggests that the latter phenomenon requires phosphate influx via the phosphate carrier. It is concluded that the earlier reports that phosphate augments the initial rate of Ca2+ influx reflects an effect of phosphate on succinate oxidation, which was employed in the previous studies, rather than an Ca2+ transport itself. |
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