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Oxazolidinones as novel human CCR8 antagonists |
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| Authors: | Jin Jian Wang Yonghui Wang Feng Kerns Jeffery K Vinader Victoria M Hancock Ashley P Lindon Matthew J Stevenson Graeme I Morrow Dwight M Rao Parvathi Nguyen Cuc Barrett Victoria J Browning Chris Hartmann Guido Andrew David P Sarau Henry M Foley James J Jurewicz Anthony J Fornwald James A Harker Andy J Moore Michael L Rivero Ralph A Belmonte Kristen E Connor Helen E |
| Institution: | Discovery Medicinal Chemistry, Molecular Discovery Research, GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, PA 19426, USA. jian.jin@gsk.com |
| Abstract: | High-throughput screening of the corporate compound collection led to the discovery of a novel series of N-substituted-5-aryl-oxazolidinones as potent human CCR8 antagonists. The synthesis, structure-activity relationships, and optimization of the series that led to the identification of SB-649701 (1a), are described. |
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