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Gestational and smoking effects on peptidase activity in the placenta |
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| Authors: | Jerilyn Kenagy Fei Liu Michael J Soares Kenneth L Audus |
| Affiliation: | * Department of Pharmaceutical Chemistry, The University of Kansas, Lawrence, KS 66047, USA † Department of Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, KS 66160, USA |
| Abstract: | Angiotensin converting enzyme (ACE) and leucine aminopeptidase (LAP) regulate fetally and maternally generated peptides in the placenta. In this study, ACE-like activity was found to be decreased and LAP-like activity increased with increasing days of gestation in rat placental tissues forming the fetal:maternal interface. Membrane-associated ACE-like and LAP-like activities in the placenta of smokers were also found to be significantly higher than their respective activities in placenta of nonsmokers. Our collective findings suggest that gestational and environmentally-induced changes in placental peptidase activities may account for variable peptide hormone and/or therapeutic peptide metabolism in the placenta. |
| Keywords: | Placenta Trophoblast Angiotensin converting enzyme Leucine aminopeptidase Development Smoking |
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